APOE and age of Alzheimer's disease onset 

 
   Lead Investigator:    Rahul Desikan
   Institution      :    University of California San Diego
   E-Mail           :    rahuldesikan@gmail.com
   Proposal ID      :    505


   Publications:


1  Bonham LW, Geier EG, Fan CC, Leong JK,  Besser L, Kukull WA , Kornak J, Andreassen OA, Schellenberg GD, Rosen HJ, Dillon WP, Hess CP, Miller BL, Dale AM, Desikan RS, Yokoyama JS
   Age-dependent effects of APOE ^{unicode 03b5}4 in preclinical Alzheimer's disease
   Journal Article  Ann Clin Transl Neurol,3:668-677,2016,PMC5018579

   PUBLISHED





   Proposal Description:
   A substantial amount of prior work indicates that the E2 and E4 alleles of apolipoprotein E (APOE) impact Alzheimer's disease (AD) age of onset. However, the impact of APOE on AD age of onset has not been evaluated in a large, neuropathologically-confirmed, population based cohort. Additionally, the impact of cardiovascular risk factors on APOE-associated AD risk factors is not known. In this proposal, using the large population based NACC cohort and a survival analysis framework, we will evaluate the role of the E2, E3 and E4 APOE alleles on age of onset in clinical AD. We will additionally evaluate the role of cardiovascular risk factors, in combination with APOE alleles, in impacting AD age of onset. We will validate these results using the pathologically confirmed NACC data.